Gastroprotective Effects of Cabbage Extracts on Ethanol-Induced Gastric Ulcer in Wistar Rats
DOI:
https://doi.org/10.63950/gshh.2025.1.2.23Keywords:
Anti-ulcer, Gastroprotective, Phytochemicals, Brassica oleracea, Antioxidants, Cimetidine, RabeprazoleAbstract
Introduction: This study investigated the gastroprotective effects of Brassica oleracea (cabbage) extracts on ethanol-induced gastric ulcers in Wistar rats, exploring a potential natural alternative to conventional medications. Various extracts of Brassica oleracea were evaluated for their ability to prevent gastric ulcers, comparing their efficacy to that of standard treatments such as cimetidine and rabeprazole.
Methods: Fifty Wistar rats were divided into ten groups, including controls and those pretreated with different doses of cabbage (Hexane, Ethyl acetate and Methanol) extracts (HEBO 500 and 1000 mg/kg, EtBO 500 and 1000 mg/kg, and MEBO 500 and 1000 mg/kg) and standard drugs (Cimetidine 50 mg/kg and Rabeprazole 20 mg/kg). Ulcer induction was performed using ethanol, and the gastroprotective effects were assessed.
Results: The HEBO 500 mg/kg and EtBO 500 mg/kg body weight extracts demonstrated significantly higher ulcer inhibition when compared to other pretreatment groups. Notably, the EtBO 500 mg/kg group exhibited the highest gastroprotective effect.
Conclusion: This research highlighted the potential of Brassica oleracea as a natural source for developing novel gastroprotective agents. Further studies are currently ongoing in our laboratory to isolate and characterise the bioactive compounds responsible for these effects.
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Copyright (c) 2025 Akinola OO, Ogunyemi A, Oyewumi SO, Kayode A (Author)
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